Prevalence and Distribution of Listeria monocytogenes inlA Alleles Prone to Phase Variation and inlA Alleles with Premature Stop Codon Mutations among Human, Food, Animal, and Environmental Isolates
نویسندگان
چکیده
منابع مشابه
A novel mutation leading to a premature stop codon in inlA of Listeria monocytogenes isolated from neonatal listeriosis.
The study objective was to investigate whether the strain of L. monocytogenes serotype 1/2c isolated from neonatal listeriosis carries a premature stop codon (PMSC) mutation in the inlA gene. The strain was characterized by serotyping, macrorestriction analysis after digestion with the restriction enzyme AscI, and sequencing of the inlA gene. The tested strain of serotype 1/2c and pulsotype 1 p...
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Epidemiological studies have provided considerable evidence that Listeria monocytogenes trains differ in their ability and relative likelihood to caus~ human disease. Multiple mutations leading to premature stop codons (PMSCs) have been identified in the key L. monocytogenes virulence gene inIA, which codes for a surface protein that mediates the entry of L. monocytogenes into host cells. Mutat...
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15 صفحه اولThe Majority of Genotypes of the Virulence Gene inlA Are Intact among Natural Watershed Isolates of Listeria monocytogenes from the Central California Coast
Internalin A is an essential virulence gene involved in the uptake of the foodborne pathogen Listeria monocytogenes into host cells. It is intact in clinical strains and often truncated due to Premature Stop Codons (PMSCs) in isolates from processed foods and processing facilities. Less information is known about environmental isolates. We sequenced the inlA alleles and did Multi Locus Variable...
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The introduction of Listeria monocytogenes into the food production chain is a concern, with numerous grouped cases of listeriosis associated with milk-derived or pork-derived products have been documented. Management of this zoonotic pathogen considers all strains as an equal risk. Recently, a new perspective for characterisation of strain virulence was introduced with the discovery of the una...
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ژورنال
عنوان ژورنال: Applied and Environmental Microbiology
سال: 2015
ISSN: 0099-2240,1098-5336
DOI: 10.1128/aem.02752-15